Therefore, in this study, we take advantage of a well-established animal model, the streptozotocin (STZ)-induced type 1 diabetic model, in comparison with the HFD-induced hyperlipidemia model, and db/db (leptin receptor deficient) type 2 diabetes model, to explore the certain effects of each metabolic disorder, especially the effects of hyperglycemia alone on NAFLD. Here, LEPR is linked to metabolic dysfunction-associated steatotic liver disease.