To get a first insight into whether the CAD risk variant SVEP1_p.D2702G (like Svep1+/− mice, carriers of this missense variant also lack wild-type SVEP1) leads to decreased SVEP1 function, we analyzed EC phenotypes after incubation with either SVEP1 or SVEP1_p.D2702G. This evidence concerns the gene SVEP1 and coronary artery disorder.