To better explore the impact of SVEP1 on atherosclerosis, we crossbred ApoE−/− mice with Svep1+/+ or Svep1+/− mice and hence generated atherosclerosis-prone mice with either normal (ApoE−/−Svep1+/+) or reduced (ApoE−/−Svep1+/−) wildtype Svep1 levels. This evidence concerns the gene APOE and atherosclerosis.