APOE and atherosclerosis: Also, the observed increased atherosclerotic plaque formation and more numerous neutrophils, Ly6Chigh monocytes, and macrophages inside plaques of ApoE−/−Svep1+/− compared to ApoE−/−Svep1+/+ mice accord with the downstream effects of CXCL1 and E-selectin in atherosclerosis [15, 37].