MR1 and cancer: Lepore et al. [7] also showed that this MR1-restricted T cell clone DGB129 (TRAV29/TRAJ23 and TRBV12-4/TRBJ1-1) can respond to MR1 in the absence of microbial antigens and can recognize cancer cells (leukemia and melanoma cell lines) through interactions with MR1 molecules produced by the cancer cells.