Lepore et al. [7] also showed that this MR1-restricted T cell clone DGB129 (TRAV29/TRAJ23 and TRBV12-4/TRBJ1-1) can respond to MR1 in the absence of microbial antigens and can recognize cancer cells (leukemia and melanoma cell lines) through interactions with MR1 molecules produced by the cancer cells. The gene discussed is MR1; the disease is melanoma.