G6PD and malaria: In G6PD, the Asn-Asp missense variant rs1050829 (allele A+), associated with G6PD deficiency and in high LD with malaria resistance variant rs1050828 (allele A−) and several other variants, shows ΠAHz of 68.8, placing it in the top 0.5% of all variants, both on the X chromosome and genome-wide (fig. 4D).