The major contributors to the rising overweight occurrence are the consumption of high‐calorie and/or fatty diets and a sedentary lifestyle both of which can lead to the onset of obesity, insulin‐resistant states such as pre‐diabetes, and can ultimately lead to the development of type 2 diabetes and other co‐morbidities (Shortreed et al., 2009; Trajcevski et al., 2013). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.