Under normal physiological conditions, skeletal muscle is responsible for most insulin‐stimulated glucose disposal in the body; therefore, skeletal muscle dysfunction due to obesity can robustly impact glucose homeostasis and insulin sensitivity (Wu & Ballantyne, 2017); thus, possibly leading to a diabetic state (Deshmukh, 2016). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.