However, there were no significant differences in synaptophysin expression between 18‐month TgF344‐AD rats compared to their 12‐month (P = 1.0) and 6‐month (P = 0.990) counterparts and, in all cases, transgenic rats displayed a lower mean synaptophysin intensity with respect to the 18‐month wild‐type rats (18m WT mean = 0.19, 95% CI = [0.17, 0.21]; 18m TG mean = 0.14, 95% CI = [0.13, 0.16]; 12m TG mean = 0.14, 95% CI = [0.10, 0.18]; 6m TG mean = 0.16, 95% CI = [0.13, 0.18]). The gene discussed is SYP; the disease is Alzheimer disease.