Upregulation of active REST was observed in the nucleus of human prefrontal cortical neurons during healthy ageing and was found to transcriptionally repress genes involved in neuronal cell death (e.g., MAPKII, FADD, PUMA) and AD‐related genes (e.g., presenilin 2, γ‐secretase and CDK5R1), thereby providing age‐related neuroprotection [13]. The gene discussed is REST; the disease is Alzheimer disease.