To investigate the potential relationship between REST levels and pathological hallmarks of AD, we also quantified changes in the abundance of protein and peptide markers associated with amyloid plaques (Aβ1–42), synaptic dysfunction (synaptophysin), age‐related neuronal atrophy (neurofilament‐H) and neuroinflammation‐induced astrogliosis, that is, glial fibrillary acidic protein (GFAP). Here, GFAP is linked to Atrophy.