The ability of plasma anti-IFNα autoantibodies to block signal transducer and activator of transcription 1 (STAT1) phosphorylation by recombinant human IFNα in vitro was assessed by flow cytometry.<h4>Results</h4>Ten SLE subjects with COVID-19 were identified. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.