This conclusion is supported by a publication of Zewinger et al. Measurements of urinary Dickkopf-3 levels, a stress-induced tubular epithelia-derived pro-fibrotic glycoprotein, in patients with IgA nephropathy predicted eGFR decline for the next a maximum of 6 months but, if repeated, also over a prolonged period of time28. This evidence concerns the gene ART4 and IgA glomerulonephritis.