Treg-cell-specific Tet2/Tet3 double conditional KO mice (Tet2flox/flox/Tet3flox/floxFoxp3Cre+ DcKO mice) show severe inflammation, resulting in inflammatory diseases, and Tregs from these DcKO mice exhibit adjusted expression levels of Treg-typical cytokine genes and dysregulation of genes involved in cancer progression35. Here, TET2 is linked to cancer.