Identifying Tet2-targeted genes/molecules in myelopoiesis and lymphomagenesis will be crucial for future studies aimed to uncover the molecular mechanisms through which Tet2 modulates hematopoiesis and serves as a tumor-suppressor gene in myelopoiesis and T/B-cell lymphomas. This evidence concerns the gene TET2 and B-cell non-Hodgkin lymphoma.