The neurotrophic regulator of Wnt-signaling, SERPINF1, demonstrates substantially increasing concentration in all groups where examined patients delivered newborns with antenatal complications and reached up to twofold changes in GDM groups (G02P and G04P) and up to 2.5-fold changes in T1DM (G07P) and T2DM (G09P) patients. Here, SERPINF1 is linked to type 2 diabetes mellitus.