The results showed that at the protein level, PARP1 (OR 1.147, 95% CI 1.067 ~ 1.233, P < 0.05), XRCC4 (OR 1.088, 95% CI 1.015 ~ 1.166, P < 0.05), XRCC1 (OR 1.114, 95% CI 1.021 ~ 1.215, P < 0.05), ERCC1 (OR 1.068, 95% CI 1.000 ~ 1.141, P < 0.10) and lymph node metastasis(≥ 10) were risk factors for postoperative metastasis of breast cancer. The gene discussed is XRCC1; the disease is breast cancer.