TP53 and Familial prostate cancer: We found that breast cancer cells (MCF7 and ZR75-1) and prostate cancer cells (LNCap) harboring wild-type p53 had higher levels of DEPTOR, whereas other cancer cells harboring mutant p53, including SK-BR3, MDA-MB-231, and DU145 and p53-null cells, such as PC3, had lower or undetectable levels of DEPTOR, indicating a positive correlation between DEPTOR protein levels and p53 activity (Figure S1C).