Intensive studies have proven that NEDD8 and enzymes of the neddylation pathway (e.g., NAE1/UBA3, UBE2M/UBE2F, and NEDD8-E3 ligases) are often overexpressed in multiple human cancers, which are associated with tumor progression and predict poor patient survival7,15. This evidence concerns the gene NEDD8 and neoplasm.