Especially, we found that transcription factors maintaining the B-cell program including PAX5 and BCL6 were downregulated, while transcription factors including PRDM1, XBP1, and IRF4 known to facilitate LLPC differentiation; PRDM1 and XBP1 required for antibody secretion; and IRF4 required for PC survival were uniquely upregulated. This evidence concerns the gene XBP1 and pachyonychia congenita.