Based on current reports on integrins in tumor research, especially in the HCC field40–45, we first tested the effect of ENO1 knockdown on the expression of related integrins (α1, α2, α3, α5, α6, αV, β1, β3, β4, and β6) in HCCLM3 cells. The gene discussed is ENO1; the disease is neoplasm.