ENO1 and hepatocellular carcinoma: To gain an in-depth understanding of the specific mechanisms by which exosomes derived from highly metastatic HCC cells promote the malignant transformation of HCC cells with low metastatic potential and promote HCC growth and metastasis, we further analyzed exosomal MS data and found that the expression of ENO1, a potential promoter of HCC progression, in addition to being highly enriched in HCCLM3exos, was also significantly upregulated in MHCC97Lexos and HepG2exos compared to in LO2exos.