TPT1 and neoplasm: As a control, WT and TCTP constitutively KD (TCTP KD) Hepa1–6 stable cell line labeled with luciferase were established (Fig. 4B) and transplanted in the livers of WT C57BL mice or TCTP+/− transgenic mice to generate three orthotopic tumor models, including WT cells transplanted in WT mice (WT/WT), TCTP KD cells in WT mice (TCTP KD/WT) and TCTP KD cells in TCTP+/− mice (TCTP KD/TCTP+/−) (40 mice for each tumor model).