DHCR7 and Niemann-Pick disease type C: Furthermore, three proteins associated with human inborn diseases, 7-dehydrocholesterol reductase (DHCR7), lesions in which cause Smith–Lemli–Opitz Syndrome (69, 70, 71), NPC1, lesions in which cause Niemann Pick Disease Type C (72, 73), and Patched, a regulator of Hedgehog signaling associated with the human cancer disorder Gorlin Syndrome (66, 74), all contain SSDs.