In the context of postinfluenza occurrence of lethal pneumococcal pneumonia, it has been shown that IL-27 expression in response to IAV infection hinders IL-17-expressing γδ T cells production by involvement of STAT1 factor and thereby deprives the host from the immunity related to IL-17 expression by γδ T cells after initial influenza infection [113]. The gene discussed is IL17A; the disease is pneumococcal pneumonia.