IFNG and neoplasm: In renal cancer, exosomes derived from glycolipid-anchored-IL-12 (GPI-IL-12) gene-modified tumor cells express the tumor-associated antigen MAGE-1 and tumor rejection antigens G250 and GPI-IL-12, which significantly promote T cell proliferation and increase interferon (IFN)-γ in turn, and efficiently trigger a stronger activity of CTLs through the FasL/Fas signaling pathway [37, 38].