The main finding of this study is that clinical parameters describing diabetes severity (e.g. diabetic polyneuropathy and insulin therapy) as well as OCT-parameters characterizing atherosclerotic extent (such as lesion length and calcium volume index) but not classical features of plaque vulnerability (e.g. FCT, extent of the necrotic lipid core, presence of macrophages or microcalcifications) predict mortality in T2DM patients following PCI (Fig. 3). Here, INS is linked to diabetic polyneuropathy.