In this analysis the clinical parameters age (HR 1.16 per year, 95% CI 1.07–1.26, p < 0.001), diabetic polyneuropathy (HR 3.58, 95% CI 1.44–8.93, p = 0.006) and insulin therapy (HR 3.25, 95% CI 1.44–8.70, p = 0.019) were significant predictors of mortality. The gene discussed is INS; the disease is diabetic polyneuropathy.