A series of studies have reported that anti-EGFR monoclonal antibody therapy was associated with improvements in both prognosis and compliance, as well as reductions in toxicity and side effects, and patients with wild-type KRAS metastatic CRC who received anti-EGFR monoclonal antibody therapy (cetuximab) and the FOLFIRI regimen (folinic acid, 5-fluorouracil, irinotecan) experienced prolonged survival up to 33.1 months [19, 20]. The gene discussed is KRAS; the disease is colorectal carcinoma.