While TNF-α increases permeability in human umbilical vascular endothelial cells (HUVECs), human colonic adenocarcinoma (Caco-2), and bovine pulmonary artery endothelial cell (BPAEC), this cytokine decreases the permeability in uterine epithelial cells (UEC) and porcine renal epithelial cells (LLC-PK1). This evidence concerns the gene TNF and colon adenocarcinoma.