SIN3A and amnesia: Furthermore, the silencing of SIN3A in the hippocampus of rats with amnesia elevated the levels of H3K9 and H3K14 acetylation in the promoter of immediate early genes (IEGs), while suppressing the binding affinity of SIN3A for the promoter of IEGs in neuron cells, thus restoring the memory functions in these rats (Srivas and Thakur 2018).