MAPT and Alzheimer disease: Using a PT76/PT76 aggregation specific MSD on different dilutions of human AD enriched PHFs (ePHF) compared to Tau fibrils derived from P301S Tau Tg mouse brain (Fig. 1b) it was possible to observe that for preps with similar Tau content (Fig. S2), the same dilutions containing ePHF result in a much higher signal compared to P301S derived seeds.