AKT1 and prostate neoplasm: Curcumin’s inhibition of prostate tumor growth and progression may be due to its inhibition of Akt expression/activation, decreased NF-κB activation, inhibition of the anti-apoptotic proteins Bcl-2 and Bcl-xL, increased expression of the proapoptotic proteins Bax and Bak, and enhanced PARP and caspase expression (Figure 4).