Generated 131I radiolabeled PSMA-monoclonal antibody (mAb) conjugated to PLGA–CUR NPs indicated that the distribution of 131I accumulated at the tumor site dose-dependently (5–20 μL), and greater accumulation occurred with PLGA–CUR NPs conjugated than with 131I radiolabeled PSMA-MAb antibodies alone. Here, FOLH1 is linked to neoplasm.