AKT1 and Familial prostate cancer: The antiproliferative, antisurvival, and antimigratory effects of curcumin in prostate cancer cells may be due to the inhibition of the Akt/mTOR, Ras/MAPK signaling pathways, decreased NF-κB activation, enhanced proapoptoptic caspase and PARP cleavage, and the inhibition of members of the antiapoptotic Bcl-2 family of proteins (Figure 3).