PTK2 and hepatocellular carcinoma: Previous studies demonstrated that the loss of histone macroH2A1 in HCC is associated with poorly differentiated, more CSC-like, and more aggressive HCC, and it also results in abnormal triglyceride accumulation [17,18,19], whereas inhibition of FAK in HCC cells reduces tumorigenicity [21] and CSC-like phenotype [22].