Comparing the results from the two sets of data, we extrapolated the expression of 32 key genes involved in reprogramming and cancer stemness acquisition (GATA6, KDR, SMAD4, TBX5, IFNG, BMP7, SOX2, NOS2, TNFRSF11A, EZH2, STAT3, AKT1, CTNNB1, ERBB2, PTK2, PTEN, VEGFA, BRCA1, POU5F1, ATM, SMAD2, KITLG, MYC, CCL2, EGF, BAX, KRT19, EGFR, NOTCH1, ABL1, JAG1, and SMAD3) (Figure 1). The gene discussed is SMAD4; the disease is cancer.