SMAD4 and cancer: Moreover, we found that FAK KD HepG2 and Huh-7 cells, but not macroH2A1 KD HepG2 and Huh-7 cells, displayed a simultaneous significant increase (p < 0.01) in the mRNA levels of cancer stemness suppressor genes GATA6, SMAD4, and BMP7, and of tumor-promoting genes KDR and SOX2 (Figure 1).