Finally, compared to macroH2A1 KD Huh-7 cells, FAK KD cells exhibited a significant reduction (p < 0.01) in the mRNA levels of tumor-promoting genes CCL2, EGF, BAX, KRT19, EGFR, NOTCH1, ABL1, and SMAD3 (Figure 1). This evidence concerns the gene SMAD3 and neoplasm.