Remarkably, while autophagy inhibition might exacerbate the effects of ACE2 loss- and Ang II-induced pro-inflammatory responses and mitochondrial alterations [130,152,153], immunoproteasome inhibition rescues autophagy and ameliorates Ang II-related hypertension, cardiac hypertrophy, and myocarditis [126,131,132,145,146,147,148,154]. This evidence concerns the gene ACE2 and hypertensive disorder.