The overall picture that comes from examination of the fatty acid remodeling occurring in obesity highlights the role of de novo lipogenesis with the formation of saturated fatty acids (SFA) and their enzymatic transformation to monounsaturated fatty acids (MUFA), connected with the functioning of delta-9 desaturase and the corresponding gene expression (SCD1, Stearoyl CoA Desaturase). Here, SCD is linked to obesity due to melanocortin 4 receptor deficiency.