It should be noted that in overweight and obesity, the decrease in desaturase delta-9 activity is significant, thus suggesting a shift in the enzyme functioning toward the SFA pathway, and (b) the role of the omega-6 pathway for the arachidonic acid increase is clearly shown in the comparison between children with normal weight and children with obesity, showing that in obesity, the increase in inflammatory signals could be crucial to be controlled in order to treat metabolic deficiencies related to childhood obesity. This evidence concerns the gene SCD and obesity due to melanocortin 4 receptor deficiency.