In line with our study using crotonoside, other Flt3 inhibitors, such as sunitinib and sorafenib, approved by Food and Drug Administration (FDA) for chemotherapy, were also demonstrated to be capable of reducing arthritis induced by methylated BSA or type II collagen in murine models [2,17,36,37,38]. The gene discussed is FLT3; the disease is arthritic joint disease.