Hofnagel and co-workers found that CXCL16 is expressed primarily in the endothelium at sites predisposed to atherosclerosis in the rabbit aorta; furthermore, anti-CXCL16 antibody treatment of primary human endothelial cells caused a significant reduction in endothelial-monocyte adhesion [175]. The gene discussed is CXCL16; the disease is atherosclerosis.