EML4 and non-small cell lung carcinoma: Crizotinib is an echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) and cMET inhibitor that has been approved for use in NSCLC [43], while dasatinib is a platelet-derived growth factor receptor/breakpoint cluster region-Abelson murine leukemia oncogene homolog-1; (PDGFR/BCR-Abl) inhibitor registered for use in chronic myeloid leukemia in a selected population [44].