Regarding the effect of this polymorphism on long-term stroke recovery or response to targeted therapies, Shiner et al. found that, after rehabilitation therapy, the motor improvement of Met carriers (at least one A allele) was significantly less when compared to non-carriers (GG allele) in patients with high or moderate motor function at baseline, while no significant effect of BDNF rs6265 on stroke patients with low motor function was found [26]. Here, BDNF is linked to stroke disorder.