BDNF and Stroke: The role of rs6265 BDNF polymorphism has been extensively studied in animal models, such as knock-in mice homozygous BDNF Met/Met, where the up-regulation of angiostatic CD36 and TSP-1 induced a reduction in endothelial cell proliferation, suggesting an association of the Met allele with stroke-induced angiogenic deficits [32].