Here, we report that fendiline is per se ineffective in inducing antitumor effects in NB cells in vitro and in vivo, but, through the inhibition of the expression of several transporters linked to multidrug resistance (ABCA1, ABCA12, SLC7A11), it greatly potentiates the antitumor efficacy of cisplatin. Here, SLC7A11 is linked to neuroblastoma.