Additionally, inverse correlations between sRAGE and S100B in T2D, and S100A6 and AGEs in IGT characterize middle age states of IGT and T2D by a shift from cytoprotective (S100A1, S100A6) to pro-apoptotic/pro-inflammatory (S100B, AGEs) RAGE ligands. Here, S100A1 is linked to type 2 diabetes mellitus.