The activation of signaling pathways by transcription factors such as NF-κB and signal transducer and activator of transcription 3 (STAT3) in colonic epithelial cells, the production of reactive oxygen species (ROS) and the related oxidative stress, DNA damage, and abnormal cell proliferation, may favor the development of colorectal adenomas and cancer [70,71,72] (Figure 1). Here, STAT3 is linked to cancer.