Genetic alterations play a key role in the progression of adenomas to CRC; for instance, mutations may occur in oncogenes (i.e., KRAS), tumor suppressor genes such as APC, p53, and CTNNB1, as well as in pathways associated with CpG island methylation (CIMP), mismatch repair (MMR), and chromosomal and microsatellite instability (CIN and MSI) [22,23,24]. This evidence concerns the gene APC and adenoma.