F. nucleatum may enhance CRC carcinogensis by stimulating the production of interleukin (IL)-17F/21/22/23/31/cluster of differentiation (CD)40L and protein expression of phospho-STAT3 (p-STAT3), p-STAT5, and phospho-extracellular regulated protein kinases (p-ERK)1/2 [95]. Here, STAT3 is linked to colorectal carcinoma.