Although at present the inhibition of the PPP is hampered by the lack of specific inhibitors and their limited clinical application, several studies showed that the uncompetitive G6PD inhibitor, dehydroepiandrosterone (DHEA) [187] inhibited the growth of early pre-neoplastic liver lesions, delayed the progression to HCC of persistent liver nodules induced by the RH model and was associated with a marked decrease of liver G6PD activity [188,189]. Here, G6PD is linked to hepatocellular carcinoma.