Similar to what observed with HK2 conditional knockout, in mouse models of K-Ras-driven non-small cell lung cancer (NSCLC) and ErbB2/Neu-driven breast cancer [140], genetic ablation of HK2 in liver-specific HK2 knockout (KO) mice (HK2 f/f; AlbCre mice) decreased the incidence of tumors in a model of DENA-induced hepatocarcinogenesis. The gene discussed is ERBB2; the disease is breast carcinoma.