Using Met-β-catenin mouse model, in which mice harbor mutant β-catenin and display c-Met co-expression by sleeping beauty transposon/transposase and hydrodynamic tail vein injection (SB-HTVI), a significant decrease in tumor volume was observed in the group treated with rapamycin, an inhibitor of mTORC1 [173]. Here, MET is linked to neoplasm.