Using a mouse model of MYC-induced liver cancer [130], it has been also observed that another important metabolic alteration in HCC is represented by a significant decrease in fatty acid oxidation (FAO) and an increase in the activity of pyruvate dehydrogenase (PDH), an enzyme complex that catalyzes the conversion of pyruvate into acetyl-CoA [133,134]. The gene discussed is PDP1; the disease is hepatocellular carcinoma.