The fact that Nrf2 plays a crucial role in HCC development by inducing metabolic reprogramming was recently supported by the finding that inhibition of the Keap1-Nrf2 pathway by thyroid hormone (T3) is associated with a switch from Warburg metabolism to OXPHOS which precedes regression of rat HCCs [145] (for a detailed description of the effect of T3, see chapter 7 entitled Pharmacological targeting of Warburg metabolism in HCC). This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.