Our previous study [14] showed good antiangiogenic potential of M. aquifolium extracts, especially MAE, and this effect may indicate that these agents are suitable for overcoming the aforementioned issue of tumor vascularization and growth at lower MMP9 levels, while lower MMP9 expression in cells treated with extracts may reduce the metastatic potential of cancer cells. This evidence concerns the gene MMP9 and neoplasm.