Results from the clinical trials showed that a dual HER2-targeted blockade (trastuzumab plus lapatinib or pertuzumab) in combination with neoadjuvant chemotherapy for HER2+ BC greatly increased pCR compared with a single HER2-targeted blockade (lapatinib or trastuzumab) plus chemotherapy (Table 2) [44,82,83,85,86,87]. Here, ERBB2 is linked to breast cancer.