TP53 and neoplasm: In fact, similar results were observed also in the glioblastoma cell line U251 and the GB8 primary glioblastoma cell line, both expressing p53 mutated [38,42]; in both cell lines, the APE treatment caused a progressive accumulation of cells in G2/M phase, suggesting that the tumor cells presenting p53 mutated present a univocal response to APE, regardless of the type of tumor.