In brief, risk factors of SARS-CoV-2 infection are active cancer, previous cardiotoxic anticancer therapies, metabolic syndrome, prior cardiovascular diseases, type 2 diabetes mellitus, hypertension, coagulopathy, shock, smoke, low or no physical activity, gene polymorphism of ectoenzyme angiotensin-converting enzyme 2 (ACE2). The gene discussed is ACE2; the disease is metabolic syndrome.