ACE2 and infection: Other considerable factors involved in ACE2 expression could be the use of some anti-inflammatory drugs such as ibuprofen [98] and PPAR (peroxisome proliferator-activated receptors) activators, which are conventionally used for the treatment of diabetes mellitus type 2, including thiazolidinediones [98]; however, their role in risk infection was hypothesized, and more studies are needed to confirm this hypothesis.