Another key regulator of ACE-2 expression is interleukin-17, which is able to maintain angiotensin II-induced hypertension and vascular dysfunction [99]; in association with interleukin 1-β (IL1-β), these cytokines induce myocarditis associated to viral infection and the use of immune checkpoint inhibitors [100,101]. The gene discussed is ACE2; the disease is hypertensive disorder.