Interleukin-1β, significantly increased in COVID-19 patients vs. healthy subjects, is one of the most important and studied cardiovascular risk factors involved in the NLRP3 inflammasome activation [105]; it has been studied for many years in cardio-oncology, in fact its expression is enhanced during doxorubicin-induced cardiotoxicity [106,107]. The gene discussed is NLRP3; the disease is COVID-19.