In human nasal epithelial cells, the depletion of sirtuin 6 (Sirt6), one of the sirtuin family members that is widely studied in aging, DNA repair, metabolism, inflammation and cancer, suppresses the number of human nasal epithelial cell cilia and dramatically induces HMGB1 translocation from the nucleus to cytoplasm [35]. This evidence concerns the gene HMGB1 and cancer.