As observed in our data, an HFF diet upregulated the SREBP-1c mRNA expression and the AE 500 treatment downregulated its expression; however, no differences were observed in the ChREBP mRNA expression, indicating that the effects on inhibiting impaired glucose tolerance promoted by AE 500 treatment may be associated with the SREBP-1c pathway and not the ChREBP pathway. Here, MLXIPL is linked to Impaired glucose tolerance.