Chemokine CCL16 (other names: HCC-4, liver expressed chemokine (LEC), liver-specific CC chemokine-1 (LCC-1)) is constitutively expressed in the liver and by hepatoma cells [6,49], as well as by monocytes treated with interleukin (IL)-10 [50]. This evidence concerns the gene CCL16 and hepatocellular carcinoma.