FLT3 and acute myeloid leukemia: Bone morphogenic protein (BMP) superfamily members, which have fundamental roles in both embryonic skeletal development and exhibit high osteogenic activity [38], were all downregulated in FLT3 ITD-positive AML patients, with a significant downregulation in the Metzeler dataset of BMP2 and BMP7. By crucially contributing in the crosstalk of OC and OB, the sphingolipid machinery has a pivotal role in bone homeostasis [39].