The aPL recognized in the international criteria include antibodies (IgG or IgM) aCL higher than 40 phospholipid units IgG or IgM or anti-β2-glycoprotein I (β2-GPI) antibodies with titers above the 99th percentile and lupus LA detected according to guidelines published by the International Society on Thrombosis and Hemostasis (ISTH). Here, CD40LG is linked to systemic lupus erythematosus.