Univariate Cox survival analysis of DLBCL patients treated with R-CHOP demonstrated that high Ann Arbor stage, poor (≥2) Eastern Cooperative Oncology Group (ECOG) performance status (PS), elevated serum LDH, involvement of two or more extranodal sites, bone marrow (BM) involvement, high international prognostic index (IPI) score, BCL2 positivity, MYC positivity, and MYC/BCL2 DE status were significantly associated with poor PFS and OS (Table S1). This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.