To explore this, we profiled one AML sample carrying the p.Gly332Arg DNMT3A variant (this sample also carries another DNMT3A variant and two frameshift variants in TET2), with AML samples extracted from TCGA and carriers of DNMT3A somatic variants known to cause global methylation alterations (i.e., the bona fide p.Arg882 DNMT3A loss-of-function alteration). Here, TET2 is linked to acute myeloid leukemia.