Although genetic polymorphisms of the SOC pathway (STIM1 and ORAI1) are not significantly associated with HCC progression after multiple correction, three SNPs of STIM1 (rs6578418, rs11030472, and rs7116520) and one SNP of ORAI1 (rs6486795) showed a borderline significant trend that should be particularly focused on in future studies. This evidence concerns the gene STIM1 and hepatocellular carcinoma.