Moreover, host genetic polymorphisms of several genes, as reported in Asian studies, could be associated with clinical outcomes of HBV-related HCC, including kinesin family member 1b (KIF1B) rs17401966 [10], major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1) rs9272105, glutamate ionotropic receptor kainate type subunit 1 (GRIK1) rs455804 [11], major histocompatibility complex, class II, DQ alpha 2 (HLA-DQA2) rs9275319, signal transducer and activator of transcription 4 (STAT4) rs7574865 [12], and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic (PIK3CA) rs17849071 [13]. This evidence concerns the gene STAT4 and hepatocellular carcinoma.