While several studies have shown the lack of effect of amantadine alone in the treatment of patients with chronic hepatitis C non-responders to IFNα2b, both in reducing viremia and in reducing alanine aminotransferase (ALT) levels [17,18], other studies have shown a sustained reduction in ALT levels in patients treated with this drug, suggesting its potential anti-inflammatory activity [12,19]. The gene discussed is IFNA2; the disease is chronic hepatitis C virus infection.