Both amantadine and memantine showed a positive effect on neurological deficits and in the improvement of rats with experimental allergic encephalomyelitis (EAE), an experimental model of multiple sclerosis, increasing both the number and activation of microglial cells, and decreasing mRNA expression of interleukin-6 (IL-6) and, to a lesser extent, expression of IL-1β, TNF-α mRNA, but did not affect the activation of astrocytes [21]. This evidence concerns the gene IL6 and multiple sclerosis.