Moreover, the monocyte hypomethylation is associated with production of a novel ncRNA from the 3′UTR with a different tissue-specificity from that of KBTBD11. Therefore, the epigenetics, transcription, and function of this previously unknown ncRNA gene encoded at the 3′ retrogene promoter of KBTBD11 should be examined in future studies of normal and cancer samples. Here, KBTBD11 is linked to cancer.