ENC1 and Mental deterioration: Two population studies of genetic and epigenetic correlates of neurological function gave evidence for differential methylation of several CpGs 1 to 2 kb upstream of the ENC1 TSS being associated with cognitive decline or schizophrenia (Figure 3F, orange and blue arrows, positions of CpGs in studies by White et al. [46] and van den Oord et al. [47], respectively).