In one of the few studies of non-promoter epigenetics of KLHL family genes, Kachroo et al. [52] found that a 0.8-kb region in the last exon of KBTBD11 was significantly hypomethylated in lymphoblasts from untreated pediatric patients with a poor-prognosis subtype of B-cell leukemia relative to those with a good-prognosis leukemia subtype. Here, KBTBD11 is linked to leukemia.